I had this on four of my Win 10 laptops out of twenty laptops. One diagnostics error would show VPN domain's tap device is down. When this problem occured the Hamachi Network Adapter Status would show nothing for IP or Subnet Mask. I could reinstall hamachi and it would be fine between reboots, but when shutting Win 10 down it would fail on the next power on. I went down the rabbit hole trying a ton of different soltuions. Turns out Windows 10 Fast Startup was enabled on the four laptops that had this problem. The other 16 laptops already had fast startup disabled. Turned it off on those four and now they are running Hamachi fine. Give it a try.
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